JAG1

JAG1
JAG1
	2KB9
Доступные структуры
PDB	Поиск ортологов: PDBe, RCSB
	Список идентификаторов PDB 2KB9, 2VJ2, 4CBZ, 4CC0, 4CC1
Идентификаторы
Символ	JAG1 ; AGS; AHD; AWS; CD339; HJ1; JAGL1
Внешние ID	OMIM: 601920 MGI: 1095416 HomoloGene: 180 GeneCards: Ген JAG1
Функция	• Notch binding; • structural molecule activity; • calcium ion binding; • protein binding; • growth factor activity;
Компонент клетки	• extracellular region; • plasma membrane; • integral component of plasma membrane; • membrane; • apical part of cell;
Биологический процесс	• angiogenesis; • cell fate determination; • morphogenesis of an epithelial sheet; • T cell mediated immunity; • pulmonary valve morphogenesis; • cardiac right ventricle morphogenesis; • Notch signaling pathway; • Notch receptor processing; • nervous system development; • hemopoiesis; • keratinocyte differentiation; • regulation of cell migration; • response to muramyl dipeptide; • aorta morphogenesis; • regulation of cell proliferation; • auditory receptor cell differentiation; • myoblast differentiation; • endothelial cell differentiation; • negative regulation of fat cell differentiation; • positive regulation of myeloid cell differentiation; • negative regulation of neuron differentiation; • positive regulation of Notch signaling pathway; • positive regulation of transcription from RNA polymerase II promoter; • cardiac septum morphogenesis; • pulmonary artery morphogenesis; • cardiac neural crest cell development involved in outflow tract morphogenesis; • Notch signaling involved in heart development; • endocardial cushion cell development; • distal tubule development; • loop of Henle development; • neuronal stem cell maintenance; • negative regulation of stem cell differentiation;
	Источники: Amigo / QuickGO
Профиль экспрессии РНК
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Ортологи

JAG1 (CD339) — мембранный белок, лиганд для рецептора Notch1, играет роль на ранних и поздних этапах гемопоэза. Мутации белка вызывают синдром Алажилля 1-го типа.